Lack of association between first myocardial infarction and past use of erythromycin, tetracycline, or doxycycline

Emerg Infect Dis. Mar-Apr 1999;5(2):281-4. doi: 10.3201/eid0502.990216.


To evaluate the association of prior treatment with antibiotics active against Chlamydia pneumoniae with the risk for incident myocardial infarction, we conducted a population-based case-control study. We found that use of erythromycin, tetracycline, or doxycycline during the previous 5 years was not associated with risk for first myocardial infarction. These results suggest little or no association between the use of these antibiotics and the risk for first myocardial infarction in the primary prevention setting.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Chlamydophila pneumoniae / drug effects*
  • Doxycycline / pharmacology*
  • Erythromycin / pharmacology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / prevention & control*
  • Retrospective Studies
  • Tetracycline / pharmacology*


  • Erythromycin
  • Tetracycline
  • Doxycycline