Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Apr 30;284(5415):770-6.
doi: 10.1126/science.284.5415.770.

Notch Signaling: Cell Fate Control and Signal Integration in Development

Affiliations
Review

Notch Signaling: Cell Fate Control and Signal Integration in Development

S Artavanis-Tsakonas et al. Science. .

Abstract

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.

Similar articles

  • [Progress in Notch signaling].
    Lu ZZ, Wang LS, Wu CT. Lu ZZ, et al. Sheng Li Ke Xue Jin Zhan. 2004 Apr;35(2):135-8. Sheng Li Ke Xue Jin Zhan. 2004. PMID: 15285419 Review. Chinese.
  • Notch signaling at a glance.
    Hori K, Sen A, Artavanis-Tsakonas S. Hori K, et al. J Cell Sci. 2013 May 15;126(Pt 10):2135-40. doi: 10.1242/jcs.127308. Epub 2013 May 31. J Cell Sci. 2013. PMID: 23729744 Free PMC article. Review.
  • [Notch signaling in the regulation of hematopoiesis].
    Vas V, Kertész Z, Pálóczi K, Uher F. Vas V, et al. Orv Hetil. 2005 Feb 13;146(7):309-16. Orv Hetil. 2005. PMID: 15782794 Review. Hungarian.
  • Regulation of notch signaling activity.
    Schweisguth F. Schweisguth F. Curr Biol. 2004 Feb 3;14(3):R129-38. Curr Biol. 2004. PMID: 14986688 Review.
  • Notch signaling.
    Artavanis-Tsakonas S, Matsuno K, Fortini ME. Artavanis-Tsakonas S, et al. Science. 1995 Apr 14;268(5208):225-32. doi: 10.1126/science.7716513. Science. 1995. PMID: 7716513 Review.
See all similar articles

Cited by 1,750 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback