Isolated oculomotor nerve palsy: an unusual presentation of glioblastoma multiforme. Case report and review of the literature

J Neurooncol. 1999 Jan;41(1):77-80. doi: 10.1023/a:1006185421774.


The authors present a case of a very unusual clinical presentation of an intra-axial supratentorial glioblastoma multiforme (GBM) in a 63 year old diabetic female patient presenting with a three week history of left progressive complete oculomotor nerve palsy. CT scan and magnetic resonance imaging of the head revealed a left intra-axial mesial temporal glioblastoma multiforme. Operative resection and microscopic examination of a tissue specimen confirmed the diagnosis. The nature of the tumor, the pattern of spread and the postulated mechanisms of such a presentation are discussed. The authors suggest including the diagnosis of GBM in the differential diagnosis of patients with isolated complete oculomotor nerve palsy at the appropriate age group.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Glioblastoma / complications
  • Glioblastoma / diagnosis*
  • Glioblastoma / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Oculomotor Nerve Diseases / diagnosis*
  • Oculomotor Nerve Diseases / etiology
  • Oculomotor Nerve Diseases / surgery
  • Supratentorial Neoplasms / complications
  • Supratentorial Neoplasms / diagnosis*
  • Supratentorial Neoplasms / surgery