[Adamantane derivatives enhancing body's resistance to emergencies]

Vestn Ross Akad Med Nauk. 1999;(3):28-32.
[Article in Russian]

Abstract

A total of 329 novel adamantane derivatives have been synthesized and pharmacologically studied. Among them, the compounds containing halogen-containing aromatic radicals in the second position show the most pronounced effect on animal resistance to the emergencies induced by its habitat and performance. N-(2-adamantyl)-N-(para-bromphenyl)amine (bromantane) possesses a low toxicity, a high ability to enhance the physical and operant working maintenance of animals, to accelerate its recovery in developed fatigue, in hyperthermia and hypoxia in particular. 2-(para-chlorobenzoylamine)adamantane (chlodantane) has the processes of a rapid-action adaptogenic agent by enhancing the resistance of animals to various physical and toxically chemical noxious agents. The two compounds have immunostimulating effects in secondary stress-induced immunodeficiencies whose mechanism of action is a membranous protective activity.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adamantane / analogs & derivatives*
  • Amantadine / analogs & derivatives*
  • Amantadine / pharmacology
  • Animals
  • General Adaptation Syndrome / prevention & control*
  • Humans
  • Mice
  • Psychotropic Drugs / pharmacology*
  • Rats
  • Stress, Psychological / drug therapy

Substances

  • Psychotropic Drugs
  • Amantadine
  • bromantane
  • Adamantane