The purpose of this study, which used a descriptive qualitative design, was to describe adolescents' experiences of the treatment regimen that follows renal transplantation in order to gain a better understanding of their experience. Five adolescents each participated in one in-depth, semistructured interview. Participants were asked to speak about the requirements of the recommended regimen related to medications, blood pressure and fluid monitoring, and diet and activity restrictions. The interviews were analyzed using Giorgi's data analysis method. The following overarching theme was identified: Weighing risks and taking chances. The consequences of the regimen and adhering or nonadhering to it were evident in the physiological, social, and psychological domains. Following the initial period, the adolescents were more selective in their adherence to the regimen, based on their perceptions of the risks involved in modifying the regimen. The modifications made to the posttransplantation regimen, which at times placed the adolescents' health at risk, were influenced by how the regimen interfered with their daily routines, such as school, leisure activities, and peer reactions as well as changes in their self-concept and self-image.