Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction

Childs Brain. 1976;2(5):273-89.


Utilizing a ventricular perfusion technique, the rate of CSF formation was determined in a 2-year-old child before and after removal of a 74 g choroid plexus papilloma from the left lateral ventricle. Preoperatively, the CSF formation rate was 1.05 +/- SD 0.01 ml/min (1,656 ml/day). Postoperatively, the CSF formation rate was reduced fivefold to 0.20 +/- SD 0.01 ml/min (288 ml/day). Whereas these data are regarded as conclusive evidence of CSF overproduction by a choroid plexus papilloma, the pathogenesis of generalized ventricular enlargement in this case was due to part to obstruction of the subarachnoid pathways.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cerebral Ventricle Neoplasms / cerebrospinal fluid*
  • Cerebral Ventricle Neoplasms / complications
  • Cerebral Ventricle Neoplasms / metabolism
  • Cerebral Ventricle Neoplasms / surgery
  • Cerebrospinal Fluid / metabolism*
  • Choroid Plexus*
  • Humans
  • Hydrocephalus / etiology*
  • Infant
  • Intracranial Pressure
  • Male
  • Papilloma / cerebrospinal fluid*
  • Papilloma / complications
  • Papilloma / metabolism
  • Papilloma / surgery