Cyclin E in human cancers

FASEB J. 1999 May;13(8):773-80. doi: 10.1096/fasebj.13.8.773.


Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E protein forms a partnership with a specific protein kinase. This complex phosphorylates key substrates to initiate DNA synthesis. Cyclin-dependent kinase inhibitors (CKIs) are able to suppress the activity of cyclin E. Various substances (including proteins produced by oncogenic viruses) affect cyclin E directly or indirectly through an interaction with CKIs. These interactions are important in elucidating the mechanisms of neoplasia. They may also provide prognostic information in a wide range of common cancers. Cyclin E may even be a target for treatment of cancers in the future.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / etiology
  • Cell Cycle / physiology
  • Cyclin E / genetics
  • Cyclin E / physiology*
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Female
  • Gastrointestinal Neoplasms / etiology
  • Gene Expression
  • Hematologic Neoplasms / etiology
  • Humans
  • Models, Biological
  • Neoplasms / etiology*
  • Oncogenic Viruses / pathogenicity
  • Retinoblastoma Protein / physiology
  • S Phase / physiology
  • Urogenital Neoplasms / etiology


  • Cyclin E
  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases