Enhanced Ornithine Decarboxylase Activity Is Associated With Attenuated Rate of Damage Evolution and Reduction of Infarct Volume in Transient Middle Cerebral Artery Occlusion in the Rat

Brain Res. 1999 May 1;826(2):325-9. doi: 10.1016/s0006-8993(99)01327-x.

Abstract

Ornithine decarboxylase (ODC) transgenic and alpha-difluoromethyl ornithine (DFMO)-treated rats were exposed to transient middle cerebral occlusion (MCAO) to examine the role of intraischaemic ODC-activity on the evolution of ischaemia-reperfusion damage. Magnetic resonance imaging (MRI) data show that the damage develops slower in ODC transgenic than in DFMO-treated rats, which is not caused by a difference in perfusion. Furthermore, infarct volumes are smaller in the former animals one day later. These data support the idea of endogenous neuroprotective action of ODC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Arterial Occlusive Diseases / diagnosis
  • Arterial Occlusive Diseases / enzymology
  • Brain Chemistry / genetics
  • Brain Ischemia / diagnosis
  • Brain Ischemia / enzymology*
  • Caudate Nucleus / blood supply
  • Caudate Nucleus / enzymology*
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / enzymology*
  • Cerebral Infarction / diagnosis
  • Cerebral Infarction / enzymology*
  • Disease Progression
  • Gene Expression Regulation, Enzymologic
  • Magnetic Resonance Imaging
  • Ornithine Decarboxylase / genetics*
  • Ornithine Decarboxylase / metabolism
  • Rats
  • Transgenes / physiology

Substances

  • Ornithine Decarboxylase