[Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid]

Rev Neurol (Paris). 1999 Feb;155(2):148-51.
[Article in French]


We studied the diagnostic value of detecting protein 14-3-3 and of assaying neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemiology research program between 1991 and 1996. Sensitivity and specificity of these two tests were high. This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases.

Publication types

  • English Abstract

MeSH terms

  • 14-3-3 Proteins
  • Cerebrospinal Fluid Proteins / analysis*
  • Creutzfeldt-Jakob Syndrome / cerebrospinal fluid*
  • Creutzfeldt-Jakob Syndrome / diagnosis
  • Creutzfeldt-Jakob Syndrome / enzymology*
  • Electroencephalography
  • Epilepsies, Myoclonic / diagnosis
  • Humans
  • Phosphopyruvate Hydratase / metabolism*
  • Predictive Value of Tests
  • Proteins / analysis*
  • Retrospective Studies
  • Tyrosine 3-Monooxygenase*


  • 14-3-3 Proteins
  • Cerebrospinal Fluid Proteins
  • Proteins
  • Tyrosine 3-Monooxygenase
  • Phosphopyruvate Hydratase