Status epilepticus: new concepts

Curr Opin Neurol. 1999 Apr;12(2):183-90. doi: 10.1097/00019052-199904000-00009.


Generalized convulsive status epilepticus is a neurological emergency characterized by abnormally prolonged seizures. This review emphasizes recent developments that bear on our understanding of the pathophysiology and management of status epilepticus. Topics include GABAA receptor modulation during prolonged seizures, the role of genetics in susceptibility to status epilepticus, neuron-specific enolas, the Veterans Administration Cooperative Study Group trial comparison of various drug regimens, utility of the electroencephalogram in patient monitoring, emerging drug therapies and patient management in out-of-hospital settings.

Publication types

  • Review

MeSH terms

  • Anticonvulsants / therapeutic use
  • Biomarkers / cerebrospinal fluid
  • Clinical Protocols
  • Critical Care / methods
  • Drug Administration Schedule
  • Electroencephalography
  • Humans
  • Phosphopyruvate Hydratase / cerebrospinal fluid
  • Receptors, GABA / physiology
  • Seizures / physiopathology
  • Status Epilepticus* / genetics
  • Status Epilepticus* / physiopathology
  • Status Epilepticus* / therapy


  • Anticonvulsants
  • Biomarkers
  • Receptors, GABA
  • Phosphopyruvate Hydratase