A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy

Maturitas. 1999 Jan 4;31(2):161-4. doi: 10.1016/s0378-5122(98)00114-5.


Objectives: To investigate the effect of vitamin K2 treatment for a year on spinal bone mineral density (BMD) in postmenopausal women, comparing with vitamin D3 hormone replacement therapy and to determine the factors which affect the efficacy of vitamin K2 therapy.

Subjects and methods: Seventy-two postmenopausal women were randomized into four groups and treated with respective agents. Before the therapy, 6 and 12 months after the treatment, their lumbar spine BMD were measured by dual energy X-ray absorptiometry. The rates of change in BMD (delta BMD) were calculated. Correlations of BMD with age, year since menopause and the initial BMD were determined.

Results: Vitamin K2 suppressed the decrease in spinal BMD as compared with no treatment group. BMD in women treated with vitamin K2 was inversely correlated with their age (r = -0.54; P < 0.05).

Conclusions: Vitamin K2 therapy may be a useful method for preventing postmenopausal spinal bone mineral loss. In addition, the therapy should be started early in postmenopausal period.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Bone Density / drug effects*
  • Cholecalciferol / pharmacology*
  • Estrogen Replacement Therapy*
  • Female
  • Humans
  • Longitudinal Studies
  • Lumbar Vertebrae
  • Middle Aged
  • Osteoporosis, Postmenopausal / prevention & control*
  • Vitamin K / analogs & derivatives*
  • Vitamin K / pharmacology
  • Vitamin K 2 / analogs & derivatives


  • Vitamin K 2
  • Vitamin K
  • Cholecalciferol
  • menatetrenone