Inhibition of mast cell-dependent anaphylaxis by succinic acid

Pharmacol Toxicol. 1999 Apr;84(4):154-8. doi: 10.1111/j.1600-0773.1999.tb00892.x.


We have examined the effect of succinic acid on anaphylaxis. Succinic acid (100 mM) significantly inhibited systemic anaphylaxis induced by compound 48/80 in mice and dose-dependently inhibited local anaphylaxis activated by anti-dinitrophenyl IgE. Further 10 and 100 mM significantly inhibited histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-dinitrophenyl IgE. In addition succinic acid (0.1 and 1 mM) had a significant inhibitory effect on anti-dinitrophenyl IgE-induced tumour necrosis factor-alpha secretion from rat peritoneal mast cells. The level of cyclic AMP in rat peritoneal mast cells, when succinic acid (100 mM) was added, transiently and significantly increased about 4 times compared with that of basal cells. These results suggest a possible use of succinic acid in managing mast cell-dependent anaphylaxis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anaphylaxis / prevention & control*
  • Animals
  • Cyclic AMP / analysis
  • Histamine Release / drug effects
  • Immunoglobulin E / immunology
  • Mast Cells / drug effects*
  • Mast Cells / physiology
  • Mice
  • Mice, Inbred BALB C
  • Rats
  • Rats, Wistar
  • Succinic Acid / pharmacology*
  • Tumor Necrosis Factor-alpha / metabolism
  • p-Methoxy-N-methylphenethylamine / pharmacology


  • Tumor Necrosis Factor-alpha
  • Immunoglobulin E
  • p-Methoxy-N-methylphenethylamine
  • Succinic Acid
  • Cyclic AMP