Association of human papillomavirus infection and disease with magnitude of human immunodeficiency virus type 1 (HIV-1) RNA plasma level among women with HIV-1 infection

J Infect Dis. 1999 Jun;179(6):1405-9. doi: 10.1086/314754.


Ninety-three women with human immunodeficiency virus type 1 (HIV-1) infection were enrolled in a cross-sectional study to evaluate the relationship between plasma HIV-1 RNA levels and coincident cervical infection and disease caused by human papillomaviruses (HPVs). HIV-1 RNA plasma levels of >10,000 copies/mL were highly associated with the presence in cervical specimens of HPV DNA of oncogenic (high risk) virus genotypes (P=.006; relative risk, 2.57). In addition, similar HIV-1 RNA plasma levels were associated with abnormal Pap smears (P=.01; relative risk, 2.11). In this study, 81% of women with high-risk HPV cervical infection had abnormal Pap smears. Measurement of HIV-1 RNA plasma levels may help to identify a subgroup of HIV-1-infected women at increased risk for cervical HPV infection and disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Cervix Uteri / pathology
  • Cervix Uteri / virology
  • Cross-Sectional Studies
  • Female
  • HIV Infections / blood*
  • HIV Infections / complications
  • HIV-1*
  • Humans
  • Middle Aged
  • New York / epidemiology
  • Outpatient Clinics, Hospital
  • Papanicolaou Test
  • Papillomaviridae*
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / epidemiology*
  • RNA, Viral / blood*
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / epidemiology*
  • Vaginal Smears


  • RNA, Viral