Soy allergy in infants and children with IgE-associated cow's milk allergy

J Pediatr. 1999 May;134(5):614-22. doi: 10.1016/s0022-3476(99)70249-0.


Objectives: To determine the prevalence of soy allergy in IgE-associated cow's milk allergy (CMA).

Study design: Children <3.5 years with documented IgE-associated CMA (n = 93) were evaluated for soy allergy by double-blind, placebo-controlled food challenge, open challenge, or convincing previous history of an anaphylactic reaction to soy. Children tolerant to soy at entry received soy formula and were followed up for 1 year.

Results: Of this IgE-associated CMA cohort (ages 3 to 41 months), 14% (95% CI = 7. 7%-22.7%) were determined to have soy allergy, 12 definitely at entry and 1 possibly after 1 year of soy ingestion. The latter child experienced severe failure to thrive at enrollment and exhibited improved growth while receiving soy during follow-up but was diagnosed with eosinophilic esophagitis at study completion. Improved growth (P <.05) occurred in the non-soy-allergic cohort ingesting soy formula (579 31 mL/d) during the year of follow-up.

Conclusions: Soy allergy occurs in only a small minority of young children with IgE-associated CMA. As such, soy formula may provide a safe and growth-promoting alternative for the majority of children with IgE-associated CMA shown to be soy tolerant at the time of introduction of soy formula.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Double-Blind Method
  • Female
  • Food Hypersensitivity / diagnosis
  • Food Hypersensitivity / immunology*
  • Humans
  • Immunoglobulin E / immunology*
  • Immunologic Tests
  • Infant
  • Infant Food / adverse effects*
  • Male
  • Milk Hypersensitivity / immunology*
  • Soybean Proteins / immunology*


  • Soybean Proteins
  • Immunoglobulin E