Iron transport across biologic membranes

Nutr Rev. 1999 Apr;57(4):114-23. doi: 10.1111/j.1753-4887.1999.tb06934.x.

Abstract

Iron is essential for life, but is toxic in excess. Nearly all organisms have therefore developed regulated mechanisms for efficient transport of iron into cells. This paper reviews the current understanding of iron transport, focusing on valuable lessons from studies of yeast iron transport and the discovery of the first mammalian transmembrane iron transporter.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Carrier Proteins / genetics*
  • Cation Transport Proteins*
  • FMN Reductase*
  • Gene Expression
  • Humans
  • Iron / metabolism
  • Iron / pharmacokinetics*
  • Iron / physiology*
  • Iron / toxicity
  • Iron-Binding Proteins*
  • Membrane Potentials
  • Mutation
  • NADH, NADPH Oxidoreductases / physiology*
  • Saccharomyces cerevisiae / metabolism

Substances

  • Carrier Proteins
  • Cation Transport Proteins
  • Iron-Binding Proteins
  • solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
  • Iron
  • FMN Reductase
  • NADH, NADPH Oxidoreductases
  • ferric citrate iron reductase