Roles of the DNA Mismatch Repair and Nucleotide Excision Repair Proteins During Meiosis

Cell Mol Life Sci. 1999 Mar;55(3):437-49. doi: 10.1007/s000180050300.

Abstract

Numerous proteins are involved in the nucleotide excision repair (NER) and DNA mismatch repair (MMR) pathways. The function and specificity of these proteins during the mitotic cell cycle has been actively investigated, in large part due to the involvement of these systems in human diseases. In contrast, comparatively little is known about their functioning during meiosis. At least three repair pathways operate during meiosis in the yeast Saccharomyces cerevisiae to repair mismatches that occur as a consequence of heteroduplex formation in recombination. The first pathway is similar to the one acting during postreplicative mismatch repair in mitotically dividing cells, while two pathways are responsible for the repair of large loops during meiosis, using proteins from MMR and NER systems. Some MMR proteins also help prevent recombination between diverged sequences during meiosis, and act late in recombination to affect the resolution of crossovers. This review will discuss the current status of DNA mismatch repair and nucleotide excision repair proteins during meiosis, especially in the yeast S. cerevisiae.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Base Pair Mismatch*
  • DNA Ligases / genetics
  • DNA Ligases / physiology*
  • DNA Repair / genetics
  • DNA Repair / physiology*
  • DNA Repair Enzymes
  • DNA, Fungal / genetics
  • DNA, Fungal / metabolism
  • DNA-Binding Proteins*
  • Endonucleases / genetics
  • Endonucleases / physiology
  • Escherichia coli Proteins*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / physiology
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology
  • Genes, Fungal
  • Humans
  • Meiosis / genetics
  • Meiosis / physiology*
  • Models, Genetic
  • MutL Proteins
  • MutS DNA Mismatch-Binding Protein
  • Pyrimidine Dimers / metabolism*
  • Recombination, Genetic
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins*
  • Single-Strand Specific DNA and RNA Endonucleases

Substances

  • Bacterial Proteins
  • DNA, Fungal
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • Fungal Proteins
  • MutL protein, E coli
  • Pyrimidine Dimers
  • Saccharomyces cerevisiae Proteins
  • Endonucleases
  • RAD1 protein, S cerevisiae
  • RAD10 protein, S cerevisiae
  • Single-Strand Specific DNA and RNA Endonucleases
  • Adenosine Triphosphatases
  • MutL Proteins
  • MutS DNA Mismatch-Binding Protein
  • MutS protein, E coli
  • DNA Ligases
  • DNA Repair Enzymes