Colonoscopic evaluation of immunochemical fecal occult blood test for detection of colorectal neoplasia

Hepatogastroenterology. Jan-Feb 1999;46(25):228-31.


Background/aims: This study was carried out to assess the validity of three testing methods of immunochemical occult blood according to the number of collection times as a means for colorectal cancer screening.

Methodology: Four thousand six hundred and eleven asymptomatic individuals, who received both an immunochemical occult blood test with a three-day method and colonoscopy during a medical checkup, served as subjects for this study. For evaluation of the desirable number of sampling times, we used the results of the first day for the 1-day method, the results of the first and second days for the 2-day method, and the results of three-consecutive days for the 3-day method. Sensitivities and specificities of these three testing methods were evaluated.

Results: Sensitivities and specificities for colorectal cancer were calculated to be 56% and 97% for the 1-day method, 83% and 96% for the 2-day method, and 89% and 94% for the 3-day method, respectively, showing a significant difference in sensitivity between the 1-day and the 2-day methods, as well as the 3-day method (p < 0.01), and in specificity between the 1-day as well as the 2-day and 3-day methods (p < 0.05).

Conclusions: These findings indicate that the immunochemical fecal occult blood test is useful for the diagnosis of colorectal cancer, and that 2-day testing is recommended as a means of screening for colorectal cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / diagnosis*
  • Adult
  • Colonoscopy*
  • Colorectal Neoplasms / diagnosis*
  • Evaluation Studies as Topic
  • Humans
  • Occult Blood*
  • Sensitivity and Specificity