Multidisciplinary treatment for gastric cancer patients by chemoimmunotherapy

Hepatogastroenterology. Jan-Feb 1999;46(25):620-5.

Abstract

Background/aims: Gastric cancer is a virulent disease with a poor prognosis despite multidisciplinary treatment. The present study was designed to clarify the clinical effects of chemoimmunotherapy for patients with advanced gastric cancer.

Methodology: The enrolled gastric cancer patients had distant metastases including liver (n = 2) and peritoneal dissemination (n = 21). The patients had received the chemotherapy according to the results of chemosensitivity test and adoptive immunotherapy by activated killer cells.

Results: There were no severe toxicities, except fever and mild myelo-suppression. Four patients had complete response (17.4%) and 10 patients had partial response (43.5%). The performance status was improved in responders (p < 0.01, from 2.6 +/- 0.5 to 1.4 +/- 0.7); however, this was not changed in non-responders (from 2.2 +/- 0.9 to 2.0 +/- 1.2). The survival of responders was longer than that of non-responders (p < 0.05, 198 +/- 69 days vs. 104 +/- 68 days).

Conclusions: It was clarified that responders by chemoimmunotherapy had a good quality of life and longer survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Combined Modality Therapy
  • Female
  • Humans
  • Immunotherapy, Adoptive*
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Peritoneal Neoplasms / secondary
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy*
  • Survival Analysis
  • Treatment Outcome