CA 125 in benign gynecological conditions

Int J Biol Markers. Oct-Dec 1998;13(4):231-7.


The tumor marker CA 125 was initially thought to be specific for ovarian malignancies. Subsequently it was found to be raised in a variety of benign conditions, including pregnancy, pelvic inflammatory disease, tuberculosis and cirrhosis of the liver. With respect to gynecological tumors, CA 125 may be elevated in benign ovarian cysts, tubo-ovarian abscess, endometriosis, hyperstimulation syndrome, ectopic pregnancy and fibroids. These results demonstrate that CA 125 is a marker of non-specific peritoneal conditions.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / blood
  • CA-125 Antigen / blood*
  • Endometriosis / blood
  • Female
  • Genital Diseases, Female / blood*
  • Genital Diseases, Female / diagnosis*
  • Humans
  • Menstruation / blood
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / diagnosis*
  • Pregnancy
  • Pregnancy, Ectopic / blood
  • Pregnancy, Ectopic / diagnosis
  • Sensitivity and Specificity


  • Biomarkers, Tumor
  • CA-125 Antigen