Neutralizing Antibody-Independent Containment of Immunodeficiency Virus Challenges by DNA Priming and Recombinant Pox Virus Booster Immunizations

Nat Med. 1999 May;5(5):526-34. doi: 10.1038/8406.

Abstract

Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Fowlpox virus / genetics
  • Injections, Intradermal
  • Lentivirus Infections / immunology*
  • Lentivirus Infections / prevention & control*
  • Macaca
  • Neutralization Tests
  • RNA, Viral / blood
  • T-Lymphocytes, Cytotoxic
  • Vaccination*
  • Vaccines, DNA / therapeutic use*
  • Viral Vaccines / therapeutic use*

Substances

  • Antibodies, Viral
  • RNA, Viral
  • Vaccines, DNA
  • Viral Vaccines