Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds

Bioorg Med Chem Lett. 1999 Apr 5;9(7):937-42. doi: 10.1016/s0960-894x(99)00114-6.


Isoxazoline containing RGD mimetics were rapidly synthesized on a solid phase to optimize linkers, regioisomers of isoxazoline scaffolds, and exosite binding groups to yield lead alphavbeta3 antagonists.

MeSH terms

  • Isoxazoles / chemistry*
  • Molecular Mimicry*
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Oligopeptides / pharmacology
  • Receptors, Vitronectin / antagonists & inhibitors*


  • Isoxazoles
  • Oligopeptides
  • Receptors, Vitronectin
  • arginyl-glycyl-aspartic acid