N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

P J Connolly; S K Wetter; K N Beers; S C Hamel; R H Chen; M P Wachter; J Ansell; M M Singer; M Steber; D M Ritchie; D C Argentieri

doi:10.1016/s0960-894x(99)00117-1

N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

Bioorg Med Chem Lett. 1999 Apr 5;9(7):979-84. doi: 10.1016/s0960-894x(99)00117-1.

Authors

P J Connolly¹, S K Wetter, K N Beers, S C Hamel, R H Chen, M P Wachter, J Ansell, M M Singer, M Steber, D M Ritchie, D C Argentieri

Affiliation

¹ The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

PMID: 10230624
DOI: 10.1016/s0960-894x(99)00117-1

Abstract

Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.

MeSH terms

Animals
Cyclooxygenase Inhibitors / chemistry
Cyclooxygenase Inhibitors / pharmacology*
Dogs
Hydroxamic Acids / chemistry
Hydroxamic Acids / pharmacology*
Hydroxyurea / analogs & derivatives*
Hydroxyurea / chemistry
Hydroxyurea / pharmacology
In Vitro Techniques
Lipoxygenase Inhibitors* / chemistry
Lipoxygenase Inhibitors* / pharmacology*

Substances

Cyclooxygenase Inhibitors
Hydroxamic Acids
Lipoxygenase Inhibitors
atreleuton
Hydroxyurea