Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

A J Cocuzza; D R Chidester; S Culp; L Fitzgerald; P Gilligan

doi:10.1016/s0960-894x(99)00133-x

Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

Bioorg Med Chem Lett. 1999 Apr 5;9(7):1063-6. doi: 10.1016/s0960-894x(99)00133-x.

Authors

A J Cocuzza¹, D R Chidester, S Culp, L Fitzgerald, P Gilligan

Affiliation

¹ DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.

PMID: 10230641
DOI: 10.1016/s0960-894x(99)00133-x

Abstract

The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.

MeSH terms

Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / pharmacology*
Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Heterocyclic Compounds
Receptors, Corticotropin-Releasing Hormone