Agreement of self-reported use of menopausal hormone replacement therapy with physician reports

Epidemiology. 1999 May;10(3):260-3.


There have been relatively few epidemiological studies to verify the information obtained from study participants on the use of menopausal hormone replacement therapy. We conducted this study as part of a case-control study of diet, hormone use, and endometrial cancer in Toronto, Ontario, Canada, 1994-1998. We compared records from 653 subjects, 30-79 years of age, with reports from their physicians on ever/never use of hormone replacement therapy and duration, type, and dose of hormone replacement therapy. A total of 88% of the interview records were in agreement with physician reports for ever/never use of hormone replacement therapy. The overall kappa value for ever/never use agreement was 0.76 (range = 0.71-0.81), and the intraclass correlation coefficient was 0.64 (range = 0.57-0.70) for duration of hormone replacement therapy use, indicating good agreement; similar correlations were seen among cases and controls for overall use, as well as estrogen- or progestogen-alone use. Concordance for brand codes was observed for about 43% of the subjects. This study suggests that information obtained by interview in case-control studies provides a reasonable measure of ever use of hormone replacement therapy and duration of use. Interviews, however, do not represent a reliable source of information on brands and dosage of hormone replacement therapy preparations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / chemically induced
  • Adenocarcinoma / epidemiology
  • Adult
  • Aged
  • Case-Control Studies
  • Diet / adverse effects
  • Endometrial Neoplasms / chemically induced
  • Endometrial Neoplasms / epidemiology
  • Estrogen Replacement Therapy / adverse effects
  • Estrogen Replacement Therapy / classification
  • Estrogen Replacement Therapy / psychology
  • Estrogen Replacement Therapy / statistics & numerical data*
  • Female
  • Humans
  • Medical Records / standards*
  • Mental Recall
  • Middle Aged
  • Ontario / epidemiology
  • Reproducibility of Results
  • Surveys and Questionnaires / standards*
  • Time Factors