[Homicide and hebephrenia-like syndrome in metachromatic leukodystrophy]

Nervenarzt. 1999 Mar;70(3):276-80. doi: 10.1007/s001150050434.
[Article in German]


We report a patient with metachromatic leukodystrophy (MLD) with a first manifestation of homicide. On admission the patient showed a hebephrenia-like syndrome with inappropriate affect, thought disorder and behavioral changes. Magnetic resonance tomography (MRT) findings suggested a diagnosis of MLD, which was confirmed by a decreased activity of leucocyte arylsulfatase A and an excessive urinary sulfatide excretion.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Arylsulfatases
  • Diagnosis, Differential
  • Homicide / psychology*
  • Humans
  • Leukodystrophy, Metachromatic / diagnosis*
  • Magnetic Resonance Imaging / methods
  • Male
  • Schizophrenia, Disorganized / diagnosis*
  • Syndrome


  • Arylsulfatases