Necrobiosis lipoidica: only a minority of patients have diabetes mellitus

Br J Dermatol. 1999 Feb;140(2):283-6. doi: 10.1046/j.1365-2133.1999.02663.x.


Although it is commonly accepted that necrobiosis lipoidica (NL) is associated with diabetes mellitus (DM), there is some controversy regarding the degree of this association. In a retrospective review of 65 patients with NL attending our dermatology out-patient clinics we found that just seven (11%) were known to have DM at the time of presentation. Seven further patients (11%) were diagnosed as having impaired glucose tolerance/DM at presentation and over a 15-year follow-up period. Thus, only a minority of our patients with NL had DM.

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adrenal Cortex Hormones / administration & dosage
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Diabetes Complications*
  • Diabetes Mellitus / genetics
  • Diabetes, Gestational / complications
  • Family Health
  • Female
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Humans
  • Male
  • Middle Aged
  • Necrobiosis Lipoidica / complications*
  • Necrobiosis Lipoidica / genetics
  • Necrobiosis Lipoidica / pathology
  • Pregnancy
  • Retrospective Studies
  • Risk Assessment
  • Time Factors


  • Adrenal Cortex Hormones