Paraproteins and monoclonal expansion of CD3+CD8+ CD56-CD57+ T lymphocytes in a patient with HIV infection

Br J Haematol. 1999 Apr;105(1):85-7.


An expansion of CD8+ lymphocytes associated with a monoclonal rearrangement of the T-cell receptor gamma locus was found in a woman with HIV-1 infection. A subpopulation of HIV-positive patients display an unusual response to HIV infection characterized by a persistent marked CD8+ lymphocytosis, the presence of which appears to be associated with an improved long-term prognosis. This condition is thought to represent a florid immune response to an ongoing viral infection which may be HIV itself, and suggests that monoclonal proliferation of CD8+ lymphocytes does not imply the presence of an underlying malignant process.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD / immunology*
  • CD5 Antigens / immunology
  • CD56 Antigen / immunology
  • CD57 Antigens / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • Female
  • HIV Infections / immunology*
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin M / deficiency
  • Immunoglobulin M / immunology
  • Lymphocytosis / immunology*
  • Lymphocytosis / virology
  • Middle Aged
  • Receptors, Antigen, T-Cell, gamma-delta / immunology


  • Antigens, CD
  • CD5 Antigens
  • CD56 Antigen
  • CD57 Antigens
  • Immunoglobulin G
  • Immunoglobulin M
  • Receptors, Antigen, T-Cell, gamma-delta