High Numbers of Clonal CD19+ Cells in the Peripheral Blood of a Patient With Multiple Myeloma

Br J Haematol. 1999 Apr;105(1):265-7.

Abstract

Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of late-stage B cells or pre-plasma cells were present in the peripheral blood (PB) of a patient with MM. During treatment the initial high level of PB clonal cells was markedly reduced and remained low (<1%) post transplant, even after disease progression. In addition, we found that the MM clone did not include a B-progenitor population defined by CD34.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD19 / metabolism*
  • B-Lymphocytes / pathology*
  • Gene Rearrangement
  • Humans
  • Immunoglobulin Heavy Chains / metabolism
  • Male
  • Middle Aged
  • Multiple Myeloma / pathology*
  • Reverse Transcriptase Polymerase Chain Reaction / methods

Substances

  • Antigens, CD19
  • Immunoglobulin Heavy Chains