Intraosseous neurofibroma of the jaws

Int J Oral Surg. 1978 Oct;7(5):494-9. doi: 10.1016/s0300-9785(78)80043-x.


Two cases of intraosseous neurofibromas of the mandible are presented. Only 25 cases of this tumor have been published previously. Of the present two cases, one was located at the upper border of the mandible, in the left second molar area where the tooth had been extracted 2 years previously. In the second case, the tumor presented itself as a 10 x 2 cm large destruction, mainly following the course of the alveolar nerve from the mandibular foramen to the mental foramen in the right side of the jaw. The mandibular first right molar was missing but the relationship between the extraction of the tooth and the development of the tumor could not be demonstrated. Histologically, the two tumors differed in the way that case 1 showed a conspicuous amount of delicate, wavy fibrils, some of which showed concentric lamellations resembling the pacinian corpuscle but without neurites containing nerve fiber bundles and also demonstrated a slight pleomorphism.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Mandible / pathology
  • Mandibular Neoplasms* / pathology
  • Mandibular Neoplasms* / surgery
  • Middle Aged
  • Molar
  • Neurofibroma* / pathology
  • Neurofibroma* / surgery
  • Tooth Extraction