[Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins]

Farmakol Toksikol. Sep-Oct 1976;39(5):631-5.
[Article in Russian]

Abstract

It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin, diosgenin and alliogenin, display the anabolic activity and do not manifest any androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augments the total amount of protein therein. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals. Castration of sexually immature rats greatly mitigates the anabolic effect of the compound IV.

Publication types

  • English Abstract

MeSH terms

  • Anabolic Agents / pharmacology*
  • Animals
  • Body Weight / drug effects
  • Kidney / drug effects
  • Liver / drug effects
  • Male
  • Muscle Proteins / metabolism
  • Muscles / drug effects
  • Organ Size / drug effects
  • Prostate / drug effects
  • Proteins / metabolism
  • Rats
  • Seminal Vesicles / drug effects
  • Spirostans / pharmacology*

Substances

  • Anabolic Agents
  • Muscle Proteins
  • Proteins
  • Spirostans