[The morphogenesis of chronic hepatitis]

MMW Munch Med Wochenschr. 1978 Nov 17;120(46):1523-30.
[Article in German]


The concept of chronic hepatitis is very complex. There is no generally recognized definition and no agreement on the nomenclature. In more recent times a subdivision into chronic persisting (CPH) and chronic active (aggressive or progressive) hepatitis (cah) has been proposed. Morphologically CPH has a mononuclear inflammatory infiltration of the portal fields with preservation of the lobules. In positive hepatitis B CPH, orcein-positive milkglass-shaped hepatocytes and washed-out nuclei have recently been established by immunofluorescence. Periportal inflammation (piecemeal necrosis) is characteristic of CAH. Severe forms show hepatocytolysis and confluent necroses in addition. Since there is not always a sharp division between CPH and CAH, an unequivocal diagnosis of clinical, biochemical, serologic and immunological data is required.

Publication types

  • English Abstract

MeSH terms

  • Chronic Disease
  • Hepatitis / pathology*
  • Humans
  • Inflammation
  • Liver / pathology*
  • Necrosis
  • Prognosis
  • Terminology as Topic*