Transcriptional activities of the orphan nuclear receptor ERR alpha (estrogen receptor-related receptor-alpha)

Mol Endocrinol. 1999 May;13(5):764-73. doi: 10.1210/mend.13.5.0281.


Estrogen receptor-related receptor alpha (ERR alpha) is an orphan nuclear receptor closely related to the estrogen receptor (ER), whose expression covers various stages of embryonic development and persists in certain adult tissues. We show that ERR alpha binds as a homodimer on a specific target sequence, the SFRE (SF-1 response element), already known to respond to the orphan nuclear receptor SF-1. Target sequences that are related to the SFRE and that discriminate between ERR alpha and SF-1 were identified. We have also analyzed the transcriptional properties of the ERR alpha originating from various species. All ERR alpha orthologs act as potent transactivators through the consensus SFRE. ERR alpha activity depends on the putative AF2AD domain, as well as on a serum compound that is withdrawn by charcoal treatment, suggesting the existence of a critical regulating factor brought by serum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cell Line
  • Charcoal
  • Culture Media
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Dimerization
  • Fushi Tarazu Transcription Factors
  • Homeodomain Proteins
  • Humans
  • Mice
  • Promoter Regions, Genetic
  • Rats
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Estrogen / genetics*
  • Receptors, Estrogen / metabolism*
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Response Elements
  • Steroidogenic Factor 1
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • Zebrafish / genetics


  • Culture Media
  • DNA-Binding Proteins
  • ERRalpha estrogen-related receptor
  • Fushi Tarazu Transcription Factors
  • Homeodomain Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Estrogen
  • Recombinant Proteins
  • Steroidogenic Factor 1
  • Trans-Activators
  • Transcription Factors
  • Charcoal