Mammalian nitric oxide synthases

Biochim Biophys Acta. 1999 May 5;1411(2-3):217-30. doi: 10.1016/s0005-2728(99)00016-x.

Abstract

The nitric oxide (NO) synthase family of enzymes generate NO from L-arginine, which acts as a biologic effector molecule in a broad number of settings. This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arginine / metabolism
  • Boranes / chemistry
  • Calmodulin / chemistry
  • Catalysis
  • Cattle
  • Mammals / metabolism*
  • Mice
  • Nitric Oxide / biosynthesis
  • Nitric Oxide Synthase / chemistry*
  • Nitric Oxide Synthase / metabolism*
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type III
  • Rats
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • Boranes
  • Calmodulin
  • Nitric Oxide
  • Arginine
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type III
  • Nos1 protein, mouse
  • Nos1 protein, rat
  • Nos2 protein, mouse
  • Nos2 protein, rat
  • Nos3 protein, mouse
  • Nos3 protein, rat