Nitric oxide in septic shock

Biochim Biophys Acta. 1999 May 5;1411(2-3):437-55. doi: 10.1016/s0005-2728(99)00031-6.


Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Endothelium, Vascular / enzymology
  • Enzyme Induction
  • Humans
  • Lipopolysaccharides
  • Liver / metabolism
  • Models, Chemical
  • Nitric Oxide / biosynthesis*
  • Nitric Oxide / chemistry
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Nitric Oxide Synthase / biosynthesis*
  • Nitric Oxide Synthase Type II
  • Shock, Septic / enzymology*
  • Shock, Septic / etiology
  • Signal Transduction


  • Lipopolysaccharides
  • Nitric Oxide
  • NOS2 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II