Abstract
The effect of intracerebroventricular injection of neuropeptide Y (NPY) was assessed on LTP in dentate gyrus. We report that NPY attenuated LTP and inhibited KCl-induced glutamate release in synaptosomes prepared from dentate gyrus. Activity of the stress-activated kinase, c-Jun NH2-terminal kinase (JNK) in synaptosomes was increased by incubation with NPY or following intracerebroventricular injection. Activation of JNK might underlie the inhibitory effect of NPY on LTP.
Copyright 1999 Elsevier Science B.V.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Action Potentials / physiology
-
Animals
-
Appetite Stimulants / pharmacology*
-
Calcium-Calmodulin-Dependent Protein Kinases / metabolism
-
Dentate Gyrus / chemistry
-
Dentate Gyrus / physiology*
-
Enzyme Activation / drug effects
-
Glutamic Acid / metabolism*
-
JNK Mitogen-Activated Protein Kinases*
-
Long-Term Potentiation / drug effects*
-
MAP Kinase Kinase 4
-
Mitogen-Activated Protein Kinase 3
-
Mitogen-Activated Protein Kinase Kinases*
-
Mitogen-Activated Protein Kinases*
-
Neuropeptide Y / pharmacology*
-
Potassium Chloride / pharmacology
-
Protein Kinases / metabolism
-
Rats
-
Rats, Wistar
-
Synapses / chemistry
-
Synapses / enzymology
-
Synaptosomes / chemistry
-
Synaptosomes / enzymology
Substances
-
Appetite Stimulants
-
Neuropeptide Y
-
Glutamic Acid
-
Potassium Chloride
-
Protein Kinases
-
Calcium-Calmodulin-Dependent Protein Kinases
-
JNK Mitogen-Activated Protein Kinases
-
Mitogen-Activated Protein Kinase 3
-
Mitogen-Activated Protein Kinases
-
MAP Kinase Kinase 4
-
Mitogen-Activated Protein Kinase Kinases