Network contraction model for cell translocation and retrograde flow

Biochem Soc Symp. 1999;65:207-22.


Kinetic and structural analysis of the actin-myosin II system in mammalian fibroblasts and fish epidermal keratocytes suggests that the cell's motility machinery arises behind the leading edge in the form of myosin filament clusters immersed in an actin filament network. We discuss how the contraction of this actin-myosin II network is related to the formation of actin-myosin filament bundles, cell translocation and retrograde flow.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / physiology
  • Cell Movement*
  • Models, Biological
  • Myosins / physiology


  • Actins
  • Myosins