Young neurons from medial ganglionic eminence disperse in adult and embryonic brain

Nat Neurosci. 1999 May;2(5):461-6. doi: 10.1038/8131.


In this study, we identified neuronal precursors that can disperse through adult mammalian brain tissue. Transplanted neuronal precursors from embryonic medial ganglionic eminence (MGE), but not from lateral ganglionic eminence (LGE) or neocortex, dispersed and differentiated into neurons in multiple adult brain regions. In contrast, only LGE cells were able to migrate efficiently from the adult subventricular zone to the olfactory bulb. In embryonic brain slices, MGE cells migrated extensively toward cortex. Our results demonstrate that cells in different germinal regions have unique migratory potentials, and that adult mammalian brain can support widespread dispersion of specific populations of neuronal precursors. These findings could be useful in repair of diffuse brain damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Tissue Transplantation*
  • Cell Movement
  • Corpus Striatum / cytology
  • Fetal Tissue Transplantation*
  • Lac Operon
  • Median Eminence / cytology
  • Median Eminence / embryology*
  • Mice
  • Mice, Inbred Strains
  • Neocortex / cytology
  • Neurons / transplantation*
  • Olfactory Bulb / cytology
  • Stem Cell Transplantation*