Thalamic and basal forebrain cholinergic connections of the rat posterior parietal cortex

Neuroreport. 1999 Apr 6;10(5):941-5. doi: 10.1097/00001756-199904060-00009.

Abstract

The thalamic connectivity and basal forebrain cholinergic input to the posterior parietal cortex (PPC) of Long-Evans rats was examined using combined retrograde tracing and immunocytochemical methods. As in previous studies, the PPC could be distinguished by its input from the lateral posterior, lateral dorsal, and posterior nuclei of the thalamus, but not the lateral geniculate nucleus or ventrobasal complex. These nuclei were also observed to receive reciprocal projections from the ipsilateral PPC. Cholinergic neurons innervating the PPC were primarily localized to the substantia innominata/nucleus basalis region. The implications of these data for possible functions of the cholinergic input to PPC are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Choline O-Acetyltransferase / metabolism*
  • Frontal Lobe / cytology
  • Frontal Lobe / physiology
  • Male
  • Molecular Probes
  • Neural Pathways / enzymology
  • Neural Pathways / physiology
  • Neurons / enzymology
  • Neurons / physiology
  • Parietal Lobe / cytology
  • Parietal Lobe / physiology*
  • Prosencephalon / cytology
  • Prosencephalon / enzymology
  • Prosencephalon / physiology*
  • Rats
  • Rats, Long-Evans
  • Thalamic Nuclei / cytology
  • Thalamic Nuclei / enzymology
  • Thalamic Nuclei / physiology*
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate

Substances

  • Molecular Probes
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Choline O-Acetyltransferase