Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome

Acta Ophthalmol Scand. 1999 Apr;77(2):234-7. doi: 10.1034/j.1600-0420.1999.770226.x.


Purpose: To report a case of Cogan-Reese syndrome.

Method: Case report. A 37-year-old man presented with Cogan-Reese syndrome.

Results: Visual acuity was 0.5 in the right eye and 1.0 in the left eye. There were corneal edema and pigmented nodules on the anterior surface of the iris, iris atrophy and ectropion uvea in the right eye. The intraocular pressure was 42 mmHg in the right eye and there was glaucomatous optic atrophy of the optic disk. Trabeculectomy with mitomycin C has been performed as the intraocular pressure did not decrease with the maximum medical treatment. Electron microscopic examination of the trabeculum and the iris tissue revealed a lot of melanocytic cells in the stroma.

Conclusion: Trabeculectomy with mitomycin C might be effective in Cogan-Reese cases with glaucoma resistant to medical treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Corneal Edema / complications
  • Corneal Edema / pathology*
  • Glaucoma / etiology
  • Glaucoma / surgery
  • Humans
  • Intraocular Pressure
  • Iris Neoplasms / complications
  • Iris Neoplasms / pathology*
  • Male
  • Mitomycin / therapeutic use
  • Nevus, Pigmented / complications
  • Nevus, Pigmented / pathology*
  • Syndrome
  • Trabeculectomy
  • Visual Acuity


  • Mitomycin