Consensus on renal cortical scintigraphy in children with urinary tract infection. Scientific Committee of Radionuclides in Nephrourology

Semin Nucl Med. 1999 Apr;29(2):160-74. doi: 10.1016/s0001-2998(99)80006-3.


A questionnaire related to cortical scintigraphy in children with urinary tract infection was submitted to 30 experts. A wide consensus was reached on several issues related to planar images: 99mTc dimercapto succinic acid (DMSA) appears as the most appropriate tracer for renal imaging; dynamic tracers are considered to be inferior, in particular 99mTc diethylenetriaminepentaacetate, which is not recommended. The general opinion is that DMSA scintigraphy is not feasible with a minimal dose below 15 MBq, whereas the maximum dose should not be higher than 110 MBq. The dose schedule generally is based on body surface area, and sedation is only exceptionally given to children. Images are obtained 2 to 3 hours after injection, preferably with high resolution collimators; pinhole images are used by only half of the experts. Posterior and posterior oblique views are used by most of the experts, and the posterior view is acquired in supine positions. At least 200.000 kcounts or 5 minute acquisition is required for nonzoomed images. As a quality control, experts check the presence of blurred or double outlines on the DMSA images. Color images are not used and experts report on film or directly on the computer screen. As far as normal DMSA images are concerned, most experts agree on several normal variants. Hydronephrosis is not a contraindication for DMSA scintigraphy but constitutes a pitfall. Differential renal function generally is measured, but no consensus is reached whether or not background should be subtracted. Most of the experts consider 45% as the lowest normal value. A consensus is reached on some scintigraphic aspects that are likely to improve and on some others that probably represent persistent sequelae. There is a wide consensus for the systematic use of DMSA scintigraphy for detection of renal sequelae, whereas only 58% of the experts are systematically performing this examination during the acute phase of infection.

Publication types

  • Consensus Development Conference
  • Review

MeSH terms

  • Child
  • Humans
  • Hydronephrosis / diagnostic imaging
  • Image Interpretation, Computer-Assisted
  • Image Processing, Computer-Assisted
  • Infant
  • Infant, Newborn
  • Kidney / diagnostic imaging*
  • Kidney Cortex / diagnostic imaging*
  • Radioisotope Renography / instrumentation
  • Radioisotope Renography / standards*
  • Radiopharmaceuticals / administration & dosage
  • Sensitivity and Specificity
  • Supine Position
  • Technetium Tc 99m Dimercaptosuccinic Acid / administration & dosage
  • Tomography, Emission-Computed, Single-Photon
  • Urinary Tract Infections / diagnostic imaging*


  • Radiopharmaceuticals
  • Technetium Tc 99m Dimercaptosuccinic Acid