Molecular chaperones: the busy life of Hsp90

Curr Biol. 1999 May 6;9(9):R322-5. doi: 10.1016/s0960-9822(99)80203-6.


The heat shock protein Hsp90 is a molecular chaperone which assists the refolding of misfolded proteins, but also has highly selective functions in normal metabolism. These dual functions enable Hsp90 to connect environmental conditions with developmental processes and to buffer genetic changes.

Publication types

  • Review

MeSH terms

  • Animals
  • HSP90 Heat-Shock Proteins / metabolism*
  • HSP90 Heat-Shock Proteins / physiology
  • Humans
  • Morphogenesis
  • Protein Kinases / metabolism


  • HSP90 Heat-Shock Proteins
  • Protein Kinases