Centromere proteins and chromosome inheritance: a complex affair

Curr Opin Genet Dev. 1999 Apr;9(2):206-17. doi: 10.1016/S0959-437X(99)80031-8.


Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inheritance with the cell cycle in several organisms. A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Centromere / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Microtubules / metabolism


  • Chromosomal Proteins, Non-Histone