Peripheral T cell survival

Curr Opin Immunol. 1999 Apr;11(2):152-6. doi: 10.1016/s0952-7915(99)80026-0.


T cell survival in the periphery is an active process, depending on continuous TCR engagement by peptide-MHC complexes and/or response to environmental cytokines. Naive T cells require interactions with the MHC restricting element. The survival requirements of memory T cells are as yet insufficiently characterized, but MHC-restricted interactions are not necessary.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Survival
  • Histocompatibility Antigens Class II / physiology
  • Humans
  • Hyaluronan Receptors / physiology
  • Immunologic Memory
  • Receptors, Antigen, T-Cell / physiology
  • T-Lymphocytes / physiology*


  • Histocompatibility Antigens Class II
  • Hyaluronan Receptors
  • Receptors, Antigen, T-Cell