B cell memory and the long-lived plasma cell

Curr Opin Immunol. 1999 Apr;11(2):172-9. doi: 10.1016/s0952-7915(99)80029-6.


The germinal center reaction is pivotal to the induction of B cell memory. The signals that regulate this complex microenvironment, with their cellular and molecular consequences, underpin long-term protective immunity. Recent studies have identified many key regulators of the germinal center cycle and have revealed an array of cellular outcomes that further define the memory B cell compartment.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology*
  • Germinal Center / physiology
  • Humans
  • Immunoglobulin G / classification
  • Immunologic Memory*
  • Plasma Cells / physiology*


  • Immunoglobulin G