Pleiotropic changes controlled by the pre-T-cell receptor

Curr Opin Immunol. 1999 Apr;11(2):135-42. doi: 10.1016/s0952-7915(99)80024-7.


The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the alphabeta lineage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Humans
  • Mice
  • Protein Precursors / physiology*
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Receptors, Antigen, T-Cell, alpha-beta / physiology*
  • Receptors, Antigen, T-Cell, gamma-delta / physiology*


  • Protein Precursors
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta