Specificity of the proteasome and the TAP transporter

Curr Opin Immunol. 1999 Apr;11(2):203-8. doi: 10.1016/s0952-7915(99)80034-x.

Abstract

The generation of antigenic peptides and their transport across the membrane of the endoplasmic reticulum for assembly with MHC class I molecules are essential steps in antigen presentation to cytotoxic T lymphocytes. Recent studies have characterized the substrate specificities of the proteasome and the transporter associated with antigen processing. It is interesting to compare the specificity of this transporter to the wide spectrum of peptides generated by the proteasome, to the binding motifs of MHC class I molecules and in particular to the principles of T cell recognition.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 2
  • ATP Binding Cassette Transporter, Subfamily B, Member 3
  • ATP-Binding Cassette Transporters / physiology*
  • Animals
  • Cysteine Endopeptidases / physiology*
  • Epitopes
  • Humans
  • Multienzyme Complexes / physiology*
  • Proteasome Endopeptidase Complex

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 2
  • ATP Binding Cassette Transporter, Subfamily B, Member 3
  • ATP-Binding Cassette Transporters
  • Epitopes
  • Multienzyme Complexes
  • TAP1 protein, human
  • TAP2 protein, human
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex