Description and prediction of peptide-MHC binding: the 'human MHC project'

Curr Opin Immunol. 1999 Apr;11(2):209-13. doi: 10.1016/s0952-7915(99)80035-1.


MHC molecules are crucially involved in controlling the specific immune system. They are highly polymorphic receptors sampling peptides from the cellular environment and presenting these peptides for scrutiny by immune cells. Recent advances in combinatorial peptide chemistry have improved the description and prediction of peptide-MHC binding. It is envisioned that a complete mapping of human immune reactivities will be possible.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Humans
  • Major Histocompatibility Complex*
  • Neural Networks, Computer
  • Peptides / metabolism*
  • Polymorphism, Genetic


  • Peptides