Control of lymphocyte development by the Ikaros gene family

Curr Opin Immunol. 1999 Apr;11(2):167-71. doi: 10.1016/s0952-7915(99)80028-4.


Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)- and TCR-mediated signaling thresholds and that the molecules exist within T cells in nuclear complexes that contain nucleosome remodeling and histone deacetylase activities.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • DNA-Binding Proteins*
  • Histones / metabolism
  • Humans
  • Ikaros Transcription Factor
  • Lymphocyte Activation
  • Lymphocytes / physiology*
  • Trans-Activators / physiology
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • Histones
  • IKZF1 protein, human
  • IKZF3 protein, human
  • Trans-Activators
  • Transcription Factors
  • Ikaros Transcription Factor