Glucose repression in yeast

Curr Opin Microbiol. 1999 Apr;2(2):202-7. doi: 10.1016/S1369-5274(99)80035-6.


The Snf1 protein kinase is a central component of the signaling pathway for glucose repression in yeast. Recent studies have addressed the regulation of Snf1 kinase activity and elucidated mechanisms by which Snf1 controls repression and activation of glucose-repressed genes. Important advances include evidence that Snf1 regulates the localization of the Mig1 repressor and that Snf1 functions at multiple points to control Cat8 and Sip4, the activators of gluconeogenic genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Fungal*
  • Glucose / metabolism*
  • Models, Genetic
  • Protein-Serine-Threonine Kinases / metabolism
  • Repressor Proteins / metabolism
  • Response Elements
  • Saccharomyces cerevisiae / physiology*
  • Signal Transduction


  • Repressor Proteins
  • SNF1-related protein kinases
  • Protein-Serine-Threonine Kinases
  • Glucose