Regulation by proteolysis: developmental switches

Curr Opin Microbiol. 1999 Apr;2(2):142-7. doi: 10.1016/S1369-5274(99)80025-3.


The energy-dependent proteases originally defined in Escherichia coli have proven to have particularly important roles in bacterial developmental systems, including sporulation in Bacillus subtilis and cell cycle in Caulobacter. Degradation of key regulatory proteins participates, with regulation of synthesis and activity of the regulators, to ensure tight control and, where required, irreversible commitment of the cell to specific developmental pathways.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Bacillus subtilis / enzymology
  • Bacteria / enzymology*
  • Caulobacter / enzymology
  • Cell Division / physiology
  • Endopeptidases / metabolism*
  • Heat-Shock Proteins / metabolism
  • Vibrio / enzymology


  • Heat-Shock Proteins
  • Endopeptidases
  • Adenosine Triphosphatases